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nAChR agonist 1

CAS No. 1394371-75-5

nAChR agonist 1 ( DUN71755 )

Catalog No. M23551 CAS No. 1394371-75-5

nAChR agonist 1 is a brain-permeable and?orally?efficacious positive?allosteric? α7?nicotinic?acetylcholine?receptor (α7 nAChR)modulator.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    nAChR agonist 1
  • Note
    Research use only, not for human use.
  • Brief Description
    nAChR agonist 1 is a brain-permeable and?orally?efficacious positive?allosteric? α7?nicotinic?acetylcholine?receptor (α7 nAChR)modulator.
  • Description
    nAChR agonist 1 is a brain-permeable and?orally?efficacious positive?allosteric? α7?nicotinic?acetylcholine?receptor (α7 nAChR)modulator.
  • Synonyms
    DUN71755
  • Pathway
    Endocrinology/Hormones
  • Target
    AChR
  • Recptor
    α7 nAChR
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1394371-75-5
  • Formula Weight
    420.0
  • Molecular Formula
    C20H18ClNO3S2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:120mg/ml(285.76mM; Need ultrasonic)
  • SMILES
    CCC(c(sc(-c(cc1)ccc1Cl)c1C)c1-c(cc1)ccc1S(N)(=O)=O)=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Sinha N, et al.Discovery?of?Novel,?Potent,?Brain-Permeable, and?Orally?Efficacious?Positive?Allosteric?Modulator?of α7?Nicotinic?Acetylcholine?Receptor?[4-(5-(4-Chlorophenyl)-4-methyl-2-propionylthiophen-3-yl)benzenesulfonamide]: Structure-Activity Relationship and Preclinical Characterization. J Med Chem.?2020 Feb 13;63(3):944-960.
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