nAChR agonist 1

CAS No. 1394371-75-5

nAChR agonist 1 ( DUN71755 )

Catalog No. M23551 CAS No. 1394371-75-5

nAChR agonist 1 is a brain-permeable and?orally?efficacious positive?allosteric? α7?nicotinic?acetylcholine?receptor (α7 nAChR)modulator.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 335 In Stock
10MG 500 In Stock
25MG 806 In Stock
50MG 1098 In Stock
100MG 1485 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
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Biological Information

  • Product Name
    nAChR agonist 1
  • Note
    Research use only, not for human use.
  • Brief Description
    nAChR agonist 1 is a brain-permeable and?orally?efficacious positive?allosteric? α7?nicotinic?acetylcholine?receptor (α7 nAChR)modulator.
  • Description
    nAChR agonist 1 is a brain-permeable and?orally?efficacious positive?allosteric? α7?nicotinic?acetylcholine?receptor (α7 nAChR)modulator.
  • Synonyms
    DUN71755
  • Pathway
    Endocrinology/Hormones
  • Target
    AChR
  • Recptor
    α7 nAChR
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1394371-75-5
  • Formula Weight
    420.0
  • Molecular Formula
    C20H18ClNO3S2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:120mg/ml(285.76mM; Need ultrasonic)
  • SMILES
    CCC(c(sc(-c(cc1)ccc1Cl)c1C)c1-c(cc1)ccc1S(N)(=O)=O)=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Sinha N, et al.Discovery?of?Novel,?Potent,?Brain-Permeable, and?Orally?Efficacious?Positive?Allosteric?Modulator?of α7?Nicotinic?Acetylcholine?Receptor?[4-(5-(4-Chlorophenyl)-4-methyl-2-propionylthiophen-3-yl)benzenesulfonamide]: Structure-Activity Relationship and Preclinical Characterization. J Med Chem.?2020 Feb 13;63(3):944-960.
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